Figure 3.

Patient-specific optimized therapy with fixed target drug concentrations. Optimized Imatinib administration returned by CT4TD for patient 0001 00004 AJR from Michor et al. (2005), in the cases of: 1-dose/day (blue) and 3-doses/day (green), with respect to: lower-bound target concentration C_targ = 0.57 [mg/L] (A–D), and optimal target concentration C_targ = 1 [mg/L] (E–H). Standard administration—i.e., 400 mg Imatinib/day—is shown with a red dashed line. In this case, the optimization is obtained on patient-specific PK parameters, without considering the PD models. (A,E) Imatinib scheduled dosage in mg (y axis), displayed on 14 days (x axis). (B–F) Imatinib concentration in blood in [mg/L] (y axis). (C–G) Variation of the cumulative distances between the observed concentration and the selected target in time. (D–H) Temporal variation of the AUC in [mg·h/L].