Figure 5.

Assessment of term weights in cost function definition. The definition of the cost function for the adjusting treatment scenario requires to set the weights of the different terms. We here considered two terms, in order to: (i) minimize the tumor burden (weight W₁), and (ii) minimize the AUC (weight W₂) (see section 3 for further details). We scanned the values of $\varphi =\frac{W_1}{W_2}$ in the range [10, 100], by repeatedly applying the CT4TD framework to the 22-patients CML dataset from Michor et al. (2005). (A) Distribution of the value of the AUC after 14-days of the optimized therapy retrieved by CT4TD (1-dose case), for distinct values of ϕ, with respect to the 22 samples in the datasets, divided in males (blue) and females (pink), and compared to the average AUC values returned by standard administration (400 mg Imatinib/day) in males (red solid line) and females (red dashed line). (B) Distribution of efficiency computed via Equation (10) on the time-average concentration over 14 days of the optimized therapy retrieved by CT4TD (1-dose case), for distinct values of ϕ, and compared to the average efficiency in the standard administration scenario (solid and dashed red lines overlap).