Figure 7.

Robustness analysis with respect to intra-patient variability. Intra-patient variability is here defined as stochastic noise randomly picked in the uniform distribution χ_r = [−σ_r, σ_r] and applied to distinct PK parameters. In particular, we here show the average and the standard deviation of the relative variation of the cost $\Delta \mathcal{L}/{\mathcal{L}}_0$, with respect to distinct levels of noise, in the cases: r = k_a (A), r = v in (B), and r = CL (C). Values of the fit are provided in Table S5.