Table 3.
Meta-analysis results: SWI mean values of PD and HC were used to calculate the effect size value and confidence interval.
| References | SN division | PD | HC | Hedge's g | SE | Confidence interval | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean | SD | N | Mean | SD | Low | High | ||||
| Ordidge et al. (22) | GlobalNA | 7 | 45.68 | 2.69 | 7 | 37.59 | 2.87 | 2.72 | 0.77 | 1.22 | 4.23 |
| Graham et al. (9) | Global* | 20 | 23.70 | 3.50 | 13 | 21.20 | 2.60 | 0.76 | 0.37 | 0.05 | 1.48 |
| Martin et al. (28) | SNc lateral** | 22 | 26.90 | 2.80 | 11 | 22.80 | 2.80 | 1.43 | 0.41 | 0.62 | 2.23 |
| SNc medial* | 29.00 | 7.20 | 25.90 | 7.30 | 0.42 | 0.37 | −0.31 | 1.15 | |||
| SNr lateral | 35.80 | 5.50 | 37.90 | 5.50 | −0.37 | 0.37 | −1.10 | 0.36 | |||
| SNr medial | 38.40 | 5.80 | 39.90 | 5.90 | −0.25 | 0.37 | −0.98 | 0.48 | |||
| Baudrexel et al. (32) | Rostral ipsilateral* | 20 | 27.17 | 3.14 | 20 | 24.45 | 2.28 | 0.97 | 0.34 | 0.31 | 1.63 |
| Rostral contralateral* | 28.01 | 3.86 | 25.32 | 2.64 | 0.80 | 0.34 | 0.15 | 1.44 | |||
| Caudal ipsilateral | 19.60 | 10.40 | 21.65 | 10.10 | −0.20 | 0.33 | −0.82 | 0.43 | |||
| Caudal contralateral | 20.04 | 10.60 | 20.75 | 7.90 | −0.07 | 0.32 | −0.69 | 0.55 | |||
| Péran et al. (29) | Right*** | 30 | 33.34 | 4.72 | 22 | 29.89 | 2.08 | 0.90 | 0.30 | 0.31 | 1.46 |
| Left*** | 32.27 | 3.90 | 29.02 | 2.11 | 0.99 | 0.30 | 0.40 | 1.56 | |||
| Focke et al. (37) | Right | 12 | 32.42 | 5.58 | 13 | 31.31 | 5.15 | 0.20 | 0.40 | −0.59 | 0.99 |
| Left | 33.03 | 4.30 | 30.20 | 4.30 | 0.64 | 0.41 | −0.17 | 1.44 | |||
| Du et al. (20) | Global*** | 40 | 33.40 | 5.42 | 28 | 28.70 | 4.19 | 0.94 | 0.26 | 0.43 | 1.45 |
| Ulla et al. (13) | SNc** | 27 | 22.58 | 0.68 | 26 | 20.65 | 0.60 | 2.96 | 0.40 | 2.18 | 3.75 |
| SNr* | 27.07 | 1.26 | 25.09 | 0.92 | 1.76 | 0.34 | 1.13 | 2.40 | |||
| Rossi et al. (23) | Medial SNc*** | 37 | 51.00 | 10.00 | 21 | 43.00 | 7.00 | 0.87 | 0.29 | 0.31 | 1.43 |
| Lateral SNc*** | 50.00 | 10.00 | 42.00 | 6.00 | 0.90 | 0.29 | 0.34 | 1.46 | |||
| Bunzeck et al. (33) | Left | 20 | 30.00 | 8.00 | 20 | 26.00 | 3.00 | 0.65 | 0.33 | 0.01 | 1.29 |
| Right | 31.00 | 8.00 | 28.00 | 3.00 | 0.49 | 0.32 | −0.14 | 1.12 | |||
| Lewis et al. (38) | Global** | 38 | 31.00 | 5.00 | 23 | 27.00 | 4.00 | 0.85 | 0.28 | 0.31 | 1.39 |
| Barbosa et al. (39) | SNc* | 20 | 52.80 | 11.70 | 30 | 47.70 | 8.40 | 0.51 | 0.32 | −0.06 | 1.09 |
| Global* | 47.70 | 8.50 | 45.70 | 6.50 | 0, 27 | 0.29 | −0.30 | 0.84 | |||
| He et al. (31) | Contralateral* | 44 | 38.90 | 5.91 | 35 | 34.90 | 4.41 | 0.75 | 0.24 | 0.29 | 1.21 |
| Ipsilateral | 38.10 | 5.26 | 34.90 | 4.41 | 0.65 | 0.23 | 0.19 | 1.10 | |||
| Reimão et al. (26) | Global | 22 | 54.02 | 19.39 | 10 | 44.37 | 17.95 | 0.50 | 0.39 | −0.26 | 1.25 |
| Lateral | 46.60 | 19.28 | 35.45 | 7.58 | 0.65 | 0.39 | −0.11 | 1.42 | |||
| Central | 50.07 | 22.47 | 40.97 | 10.46 | 0.45 | 0.39 | −0.30 | 1.21 | |||
| Medial | 58.27 | 15.96 | 49.77 | 17.73 | 0.50 | 0.39 | −0.26 | 1.26 | |||
| Murakami et al. (40) | Global* | 21 | 30.10 | 1.50 | 21 | 29.00 | 2.00 | 0.61 | 0.32 | −0.01 | 1.23 |
| Pyatigorskaya et al. (8) | Global* | 20 | 27.80 | 1.50 | 20 | 25.10 | 2.10 | 1.45 | 0.36 | 0.75 | 2.15 |
| Wieler et al. (41) | Lateral SNc* | 19 | 26.23 | 3.08 | 13 | 22.82 | 5.13 | 0.83 | 0.38 | 0.09 | 1.56 |
| Guan et al. (30) | SNc* | 60 | 28.18 | 3.57 | 40 | 25.25 | 3.03 | 0.86 | 0.22 | 0.45 | 1.28 |
| SNr | 43.79 | 5.28 | 40.94 | 5.71 | 0.52 | 0.21 | 0.11 | 0.93 | |||
| Hopes et al. (10) | Left* | 70 | 46.44 | 2.17 | 20 | 37.60 | 0.87 | 4.46 | 0.42 | 3.64 | 5.29 |
| Right* | 46.22 | 2.31 | 36.90 | 1.16 | 4.37 | 0.42 | 3.56 | 5.18 | |||
| Isaias et al. (12) | Ipsilateral | 18 | 41.17 | 10.96 | 18 | 37.47 | 5.16 | 0.42 | 0.34 | −0.24 | 1.08 |
| Contralateral | 43.30 | 10.01 | 39.09 | 5.74 | 0.50 | 0.34 | −0.16 | 1.17 | |||
| Langkammer et al. (42) | Global* | 66 | 41.10 | 8.70 | 58 | 37.60 | 5.80 | 0.46 | 0.18 | 0.11 | 0.82 |
| Du et al. (43) | SNc*** | 72 | 28.00 | 0.40 | 62 | 25.90 | 0.40 | 5.22 | 0.37 | 4.51 | 5.93 |
| SNr** | 41.50 | 1.00 | 37.30 | 1.10 | 3.98 | 0.30 | 3.40 | 4.58 | |||
| Langley et al. (13) | SNc cohort 1*** | 32.50 | 5.60 | 32 | 27.50 | 4.30 | 0.98 | 0.26 | 0.48 | 1.48 | |
| SNr cohort 1* | 37.80 | 5.40 | 32 | 35.40 | 5.20 | 0.44 | 0.25 | −0.03 | 0.93 | ||
| SNc cohort 2*** | 42 | 34.30 | 4.90 | 46 | 29.50 | 4.40 | 1.02 | 0.23 | 0.58 | 1.47 | |
| SNr cohort 2 | 40.70 | 6.00 | 39.20 | 8.40 | 0.20 | 0.21 | −0.22 | 0.62 | |||
| Pesch et al. (16) | Global | 35 | 49.35 | 6.46 | 35 | 45.78 | 2.98 | 0.71 | 0.25 | 0.22 | 1.18 |
| Ghassaban et al. (44) | Right* | 25 | 42.00 | 4.00 | 24 | 39.00 | 4.00 | 0.74 | 0.30 | 0.16 | 1.32 |
| Left* | 25 | 43.00 | 4.00 | 39.00 | 4.00 | 0.98 | 0.31 | 0.39 | 1.58 | ||
| Arribarat et al. (11) | Posterior | 18 | 25.96 | 3.12 | 21 | 25.02 | 2, 14 | 0.35 | 0.33 | −0.29 | 0.98 |
| Anterior** | 31.05 | 3.61 | 27.26 | 2.97 | 1.13 | 0.35 | 0.45 | 1.81 | |||
| Global*** | 34.47 | 3.03 | 29.96 | 2.97 | 1.47 | 0.36 | 0.76 | 2.19 | |||
| Li et al. (14) | Global | 28 | 35.78 | 5.08 | 28 | 35.37 | 4.35 | 0.09 | 0.27 | −0.44 | 0.61 |
All SN subdivisions are included.
*
Significantly different from controls (p < 0.05).
**
Significantly different from controls (p < 0.005).
***
Significantly different from controls (p < 0.001). NA, non available.