Table 1.
Characteristics of ECMO-supported and non-ECMO-supported neonates with severe ARDS.
| Characteristics | ECMO (n = 42) | Non-ECMO (n = 103) | P-value |
|---|---|---|---|
| BASIC INFORMATION | |||
| Age at admission (h), median (IQR) | 6.75 (5~13.25) | 8 (4~15) | 0.99 |
| GA (Weeks), median (IQR) | 39 (37+5~40) | 39+4 (38+1~40+3) | 0.32 |
| Body weight (g) | 3,362 ± 487.73 | 3243.4 ± 542.61 | 0.221 |
| Sex n (%) | 0.216 | ||
| Male | 31 (73.8%) | 65 (63.1%) | |
| Female | 11 (26.2%) | 38 (36.9%) | |
| Delivery, n (%) | 0.145 | ||
| Spontaneous labor | 15 (35.7%) | 23 (23.7%) | |
| Cesarean delivery | 27 (64.3%) | 74 (76.3%) | |
| Diagnosis, n (%) | 0.002** | ||
| MAS | 17 (40.5%) | 19 (18.4%) | |
| Sepsis | 8 (19.0%) | 10 (9.7%) | |
| Pneumonia | 11 (26.2%) | 61 (59.2%) | |
| Asphyxia | 6 (14.3%) | 13 (12.6%) | |
| ILLNESS SEVERITY METRICS PRE-ECMO | |||
| OI, median (IQR) | 51.2 (42.2~63.9) | 25 (18.8~35.958) | <0.001** |
| PH, median (IQR) | 7.2 (7.1~7.3) | 7.3 (7.2~7.4) | 0.024* |
| PaO2, median (IQR) | 34.9 (30~41.2) | 34 (28.9~46) | 0.794 |
| PaCO2, median (IQR) | 53.0 (39.5~61.5) | 42.8 (37~52) | 0.012* |
| BE, median (IQR) | −9.9 (−15.5~-2.5) | −5.1 (−7.7~-1.9) | 0.009** |
| Lactate, median (IQR) | 8.8 (4.8~14.9) | 4.2 (2.8~5.5) | <0.001** |
| Treatment pre-ECMO | |||
| NO, n (%) | 29 (69.0%) | 41 (39.8%) | 0.001** |
| PS, n (%) | 36 (85.7%) | 88 (85.4%) | 0.966 |
| Ventilator mode, n (%) | <0.001 | ||
| HFOV | 24 (57.1%) | 86 (84.3%) | |
| CMV | 18 (42.9%) | 16 (15.7%) | |
ECMO, extracorporeal membrane oxygenation; IQR, interquartile range; GA, gestational age; MAS, meconium aspiration syndrome; OI: oxygenation index; BE, base excess; NO, nitrix oxide; PS, pulmonary surfactant; HFOV, high frequency oscillatory ventilation; CMV, conventional mechanical ventilation;
*
P < 0.05;
**
P < 0.01.