Table 1.
Parameters assessed for in-vivo DN model generation
| Parameters | Control (n = 6, ±SD) | Diabetic (n = 6, ±SD) | Diabetic + miR-29b mimics (n = 6, ±SD) | Negative control (scramble) (n = 6, ±SD) |
|---|---|---|---|---|
| Blood glucose (mmol) | 9.94 ± 0.515 | 29.7 ± 2.531*** | 22.94 ± 3.688*** | 33.33 ± 3.157 |
| Creatinine clearance (ml/min) | 0.105 ± 0.033 | 0.0699 ± 0.027 | 0.0786 ± 0.034 ns | 0.066 ± 0.016* |
| Serum BUN | 26.36 ± 1.976 | 33.43 ± 1.97* | 29.88 ± 1.04 ns | 31.087 ± 4.77* |
| Serum creatinine (μmol/L) | 69.246 ± 11.749 | 91.3466 ± 12.07* | 76.613 ± 17.382 ns | 92.82 ± 7.396* |
| NAG activity (U/L) | 0.004 ± 0.001 | 0.032 ± 0.010*** | 0.0206 ± 0.004* | 0.029 ± 0.008*** |
| HbA1c (%) | 0.74 ± 0.440 | 9.041 ± 0.252*** | 8.60 ± 1.096*** | 11.036 ± 1.812*** |
| UAER (μg/min) | 0.00750 ± 0.0011 | 0.583 ± 0.098*** | 0.452 ± 0.232*** | 0.667 ± 0.180*** |