Table 1.
(A) Patients' and controls' gender, age, and scanner distribution. (B) Subjects' characteristics including cognitive profile measured with the Edinburgh cognitive and behavioural ALS screen (ECAS) for statistical comparison.
| (A) | ||||
|---|---|---|---|---|
| gender (m/f) | Age/years | age range/years | MRI scanner 1.5 T/3.0 T | |
| C9orf72 | 17/10 | 62 ± 12 | 34–78 | 22/5 |
| controls A | 23/9 | 59 ± 16 | 24–82 | 26/6 |
| p (t-test) | 0.47 | 0.49 | – | 0.98 |
| SOD1 | 8/7 | 55 ± 13 | 37–79 | 12/3 |
| controls B | 12/9 | 54 ± 14 | 24–73 | 17/4 |
| p (t-test) | 0.69 | 0.90 | – | 0.94 |
| (B) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ECAS total score | memory | visuospatial | language | Verbal fluency | executive function | ALS-FRS-R median (range) | dis.dur./months median (range) | years of education | Handedness (right/left) | site of onset (spinal/bulbar) | |
| C9orf72 | 30 ± 8 | 13 ± 5 | 11 ± 2 | 22 ± 6 | 15 ± 5 | 30 ± 8 | 40 (34 – 48) | 12 (3 – 37) | 12.8 ± 3.8 | 26/1. | 18/9 |
| SOD1 | 107 ± 8 | 16 ± 2 | 12 ± 1 | 24 ± 4 | 17 ± 4.3 | 38 ± 4 | 44 (29 – 48) | 13 (4 – 48) | 13.7 ± 3.3 | 13/2. | 15/0 |