Table 2.
Cox-regression analysis of factors associated with overall survival
| Factor | Univariate | Multivariate | ||
|---|---|---|---|---|
|
|
|
|||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | ||||
| ≤46 | Reference | |||
| >46 | 1.102 (0.535-2.268) | 0.793 | - | - |
| Gender | ||||
| Male | Reference | |||
| Female | 1.194 (0.512-2.784) | 0.682 | - | - |
| Histology | ||||
| WHO I | ||||
| WHO II | Reference | - | - | |
| WHO III | 0.700 (0.340-1.442) | 0.334 | - | - |
| Clinical stage (UICC) | ||||
| I | Reference | 0.003 | Reference | 0.025 |
| II | 0.000 (0.000-) | 0.977 | 0.000 (0.000-) | 0.981 |
| III | 0.131 (0.024-0.720) | 0.619 | 0.213 (0.027-1.674) | 0.141 |
| IV | 0.179 (0.039-0.820) | 0.027 | 0.241 (0.043-1.345) | 0.105 |
| V | 0.656 (0.149-2.896) | 0.578 | 1.046 (0.221-4.984) | 0.955 |
| T classification | ||||
| T1 | Reference | 0.124 | ||
| T2 | 0.856 (0.287-2.558) | 0.781 | - | - |
| T3 | 0.447 (0.181-1.101) | 0.080 | - | - |
| T4 | 0.340 (0.121-0.957) | 0.041 | - | - |
| N classification | ||||
| N0 | Reference | 0.004 | ||
| N1 | 0.096 (0.025-0.373) | 0.001 | - | - |
| N2 | 0.303 (0.109-0.838) | 0.021 | - | - |
| N3 | 0.286 (0.112-0.729) | 0.009 | - | - |
| Carotid sheath involvement | ||||
| No | Reference | |||
| Yes | 0.744 (0.259-2.132) | 0.582 | - | - |
| Nasal cavity involvement | ||||
| No | Reference | |||
| Yes | 0.765 (0.358-1.636) | 0.490 | - | - |
| Maxillary sinus involvement | ||||
| No | Reference | |||
| Yes | 0.595 (0.273-1.301) | 0.193 | - | - |
| Neck lymph node level involvement | ||||
| No | Reference | 0.010 | ||
| Level I | 0.096 (0.025-0.373) | 0.001 | - | - |
| Level II | 0.266 (0.033-2.168) | 0.216 | - | - |
| Level III | 0.307 (0.107-0.880) | 0.028 | - | - |
| Level IV | 0.286 (0.112-0.731) | 0.009 | - | - |
| Maximum neck lymph node diameter | ||||
| <20 mm | Reference | |||
| ≥20 mm | 0.479 (0.224-1.024) | 0.058 | - | - |
| INHBA expression | ||||
| Low | Reference | |||
| High | 2.687 (1.227-5.883) | 0.013 | - | - |