Table 3.

Cox-regression analysis of factors associated with disease-free survival

Factor	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value
Age
≤46	Reference
>46	1.108 (0.578-2.124)	0.757	-	-
Gender
Male	Reference
Female	1.152 (0.543-2.441)	0.713	-	-
Histology
WHO I
WHO II	Reference		-	-
WHO III	1.303 (0.676-2.513)	0.429	-	-
Clinical stage (UICC)
I	Reference	0.011	Reference	0.040
II	0.000 (0.000-)	0.973	0.000 (0.000-)	0.974
III	0.117 (0.027-0.498)	0.004	0.183 (0.041-0.810)	0.025
IV	0.203 (0.058-0.715)	0.013	0.274 (0.077-0.977)	0.046
V	0.457 (0.130-1.607)	0.222	0.624 (0.174-2.232)	0.468
T classification
T1	Reference	0.472
T2	0.906 (0.303-2.703)	0.589	-	-
T3	0.511 (0.211-1.234)	0.136	-	-
T4	0.729 (0.307-1.731)	0.474	-	-
N classification
N0	Reference	0.005
N1	0.163 (0.056-0.473)	0.001	-	-
N2	0.293 (0.112-0.761)	0.012	-	-
N3	0.303 (0.126-0.727)	0.007	-	-
Carotid sheath involvement
No	Reference
Yes	0.564 (0.200-1.592)	0.280	-	-
Nasal cavity involvement
No	Reference
Yes	0.521 (0.270-1.005)	0.052	-	-
Maxillary sinus involvement
No	Reference
Yes	0.679 (0.328-1.403)	0.296	-	-
Neck lymph node level involvement
No	Reference	0.006
Level I	0.163 (0.056-0.471)	0.001	-	-
Level II	0.205 (0.026-1.647)	0.136	-	-
Level III	0.441 (0.173-1.122)	0.086	-	-
Level IV	0.242 (0.098-0.595)	0.002	-	-
Maximum neck lymph node diameter
<20 mm	Reference
≥20 mm	0.556 (0.286-1.080)	0.083	-	-
INHBA expression
Low	Reference		Reference
High	2.710 (1.337-5.494)	0.006	0.442 (0.214-0.914)	0.028