Table 7.
Alternative B T-cell (MHC Class-I and II) peptides for all five species of EBOV have been shown. The peptides were predicted using the IEDB Analysis Resource. Residues in boldface are indicating the variations.
| Peptide | MHC Class-I Peptides |
||||
|---|---|---|---|---|---|
| Zaire | Sudan | Tai Forest | Bundibugyo | Reston | |
| P1 | FHKEGAFFLYDRL | FHKDGAFFLYDRL | FHKEGAFFLYDRL | FHKEGAFFLYDRL | FHKNGAFFLYDRL |
| P2 | YWTTQDEGAAIGL | NA | YWTALDEGAAIG | YWTTQDEGAAIGL | YWTAVDEGAAVGL |
| P3 | MHNQDGLICGL | MHNQNALVCGL | MENQNGLICGL | MHNQNGLICGL | MHNQNGLICGL |
| P4 | FLRATTELRTFS | FLRATTELRTYT | FLRATTELRTFS | FLRATTELRTFS | FLRATTELRTYS |
| P5 | AIGLAWIPY | AAGIAWIPY | AIGLAWIPY | AIGLAWIPY | AVGLAWIPY |
| MHC Class-II Peptides | |||||
| P1 | WVIILFQRTFSIPL | WVIILFQKAFSMPL | WVIILFHKVFSIPL | WVIILFHKVFPIPL | WVIILFQRAISMPL |
| P2 | IRGFPRCRY | VRGFPRCRY | NA | VRGFPRCRY | VRGFPRCRY |
| P3 | VVAFLILPQ | NA | VIAFLILPK | VVAFLILPK | VVAFLILSE |
| P4 | DKLVCRDKLSS | NA | DKFVCRDKLSS | DKLVCRDKLSS | DQLVCRDKLSS |
| P5 | LQLFLRATTELR | LQLFLRATTELR | LQLFLRATTELR | LQLFLRATTELR | LQLFLRATTELR |
| B-Cell Peptides | |||||
| P1 | GFRSGVPPKVVNYE | GFRSGVPPKVVSYE | GFRAGVPPKVVNYE | GFRAGVPPKVVNYE | GFRSGVPPKVVSYE |
| P2 | QRWGGTCHILGPDC | RRWGGTCRILGPDC | QRWGGTCHILGPDC | QRWGGTCHILGPDC | QRWGGTCRILGPSC |
| P3 | LHYWTTQDEGAAIG | NA | LHYWTALDEGAAIG | LHYWTTQDEGAAIG | LHYWTAVDEGAAVG |
| P4 | WIPAGIGVTGVIIA | WIPAGIGITGIIIA | WVPAGIGITGVIIA | WVPAGIGITGVIIA | WIPAGIGIIGVIIA |
| P5 | KEGAFFLYDRLAST | KDGAFFLYDRLAST | KEGAFFLYDRLAST | KEGAFFLYDRLAST | KNGAFFLYDRLAST |