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. 2020 Mar 30;5(6):891–904. doi: 10.1016/j.ekir.2020.03.020

Figure 1.

Figure 1

Genome-wide association map (Manhattan Plot) showing relative APOL1 mRNA expression in 50 primary renal proximal tubule cell lines from African American individuals without nephropathy. A total of 731,553 variants with minor allele frequencies >0.05 were evaluated. X-axis refers to chromosomal single nucleotide polymorphism (SNP) location; y-axis represents negative log transformed P values for SNP association with APOL1 expression. (a) SNPs associated with baseline APOL1 expression; (b) SNPs associated with polyinosinic-polycytidylic acid (poly IC)–stimulated APOL1 expression; (c) SNPs associated with the difference in APOL1 expression (post–poly IC minus baseline). ∗Change reflects difference in APOL1 gene expression (after poly IC vs. baseline).