Table 1.
Association between top SNPs with relative APOL1 mRNA expression in primary renal PTC lines from African American individuals
| SNP | Position | Condition | Allele (M/m) | Adjacent gene ID | Model | P value | Beta (SE) | mAF | MM (n) | Mm (n) | mm (n) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs6559850 | 9:72531390 | Baseline | C/T | MAMDC2 | Dom | 7.4 × 10−7 | 1.03 (0.18) | 0.17 | 35 | 13 | 2 |
| rs513349 | 6:33541719 | Poly IC | G/A | BAK1 | Add | 2.4 × 10−7 | 0.88 (0.15) | 0.34 | 23 | 20 | 7 |
| rs142546651 | 3:164915128 | Changea | C/G | SLITRK3 | Dom | 4.1 × 10−9 | 1.37 (0.20) | 0.07 | 44 | 5 | 1 |
| rs148695969 | 13:65987966 | Changea | T/G | Dom | 5.1 × 10−9 | 1.48 (0.21) | 0.05 | 45 | 5 | 0 |
Beta, estimate was determined by the effect of minor allele; M, major allele; m, minor allele; mAF, minor allele frequency; poly IC, in polyinosinic-polycytidylic acid; PTC, proximal tubule cell; SNP, single nucleotide polymorphism.
SNP position based on human reference sequence (GRCh37). Genetic models Dom and Add refer to dominant and additive, respectively. P values adjusted for African ancestry proportion. Individuals had an estimated glomerular filtration rate >60 ml/min per 1.73 m2 (N = 50).
a
Change: difference between poly IC vs. baseline.