Table 3.
Summary of potential targets and pathways of TP73-AS1.
| Cancer type | Expression | Potential target | Pathway | References |
|---|---|---|---|---|
| GC | Upregulated | NA | Cell proliferation, apoptosis, invasion and metastatic properties; tumorigenesis; cisplatin resistance; Bcl-2/caspase-3 pathway; EMT; WNT/β-catenin signaling pathway; HMGB1/RAGE signaling pathway; miR-194-5p/SDAD1 axis | 9,16–18 |
| Breast cancer | Upregulated | miR-200a; miR-490-3p | Cell invasion, migration and vasculogenic mimicry; TFAM; TP73-AS1/miR-200a/ZEB1 regulating loop; miR-490-3p/TWIST1 axis | 13,19,33 |
| Ovarian cancer | Upregulated | p21; EZH2 | Cell proliferation, apoptosis, invasion and migration; tumor growth; MMP2 and MMP9 | 20,21,36 |
| Osteosarcoma | Upregulated | miR-142 | Cell proliferation, migration and invasion; tumor growth; TP73-AS1/miR-142/Rac1 signaling pathway | 12,22 |
| Brain glioma | Upregulated | miR-142; miR-124 | Cell proliferation and invasion; temozolomide resistance; HMGB1/RAGE pathway; ALDH1A1; TP73-AS1/miR-124/iASPP axis | 23,37,38 |
| HCC | Upregulated | miR-200a | Cell proliferation; HMGB1/RAGE pathway and NF-кB expression | 11 |
| Pancreatic cancer | Upregulated | miR-141 | Cell migration, invasion and metastasis; BDH2 | 24 |
| LAD | Upregulated | NA | Cell proliferation, apoptosis, migration and invasion; tumor growth and metastasis; PI3K/AKT pathway | 25 |
| NSCLC | Upregulated | miR-449a | Cell growth and cycle progression; TP73-AS1/miR-449a/EZH2 axis | 19 |
| Bladder cancer | Downregulated | NA | Cell proliferation, apoptosis, migration and invasion; EMT | 10 |
| ccRCC | Upregulated | KISS1 | Cell proliferation, invasion and apoptosis; PI3K/Akt/mTOR pathway | 26 |
| CCA | Upregulated | NA | Cell proliferation, apoptosis and metastatic properties; tumor growth | 13 |
| CRC | Downregulated | miR-103; miR-194 | Cell proliferation, apoptosis migration and invasion; tumor growth; TP73-AS1/miR-103 axis; PTEN; TP73-AS1/miR-194/TGFα axis | 27,39 |