Figure 8.
Nrf-2-mediated antioxidative response. (a) Nrf-2 nuclear protein levels and Nrf-2 downstream activity in wild-type mice supplemented with atherogenic diet constituents represented by HO-1 relative mRNA levels (Figure 7), GST-1α relative mRNA levels, GCLC relative mRNA levels, NQO-1 relative mRNA levels, and CCNA2 (cyclin A2) relative mRNA levels. All values are expressed as mean ± SEM (n = 8). (b) Nrf-2 nuclear protein levels and Nrf-2 downstream activity in Mdr2-/- mice treated or not with cholesterol. Nrf-2 activity is represented by HO-1 relative mRNA levels (Figure 7), GST-1α relative mRNA levels, GCLC relative mRNA levels, NQO-1 relative mRNA levels, and CCNA2 (cyclin A2) relative mRNA levels. All values are expressed as mean ± SEM (n = 7). Means with different letters are statistically different, p < 0.05.