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. 2020 Jun 3;11:2798. doi: 10.1038/s41467-020-16651-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Average distribution of DNA methylations over med12 downregulated genes in three different sequence contexts (left to right, CG, CHG, and CHH). Control represents a group of randomly selected MED12 non-DEGs of similar expression levels. −2 kb and +2 kb represent 2 kb upstream of transcription start site (TSS) and 2 kb downstream of transcription termination site (TTS), respectively. b Same as in a, except for med12 upregulated genes. c Average distribution of histone modifications over med12 DEGs, distinguishing genes downregulated (green) and upregulated (purple) in med12 from corresponding controls of similar expression levels (orange and pink, respectively). Top row from left to right, H3, H3K4me3, H3K9me2; Bottom row from left to right, H3K27me3, H3K36me3, H3PanAc. Shaded area represents the standard error (SEM) centered on mean value (dark solid lines). n = 3 biologically independent samples.