. 2020 Jun 3;10:9070. doi: 10.1038/s41598-020-65911-3

Table 3.

Alphabetically ordered and white-spaced list of OT-sample transcripts (HGNC gene symbol used) that were over-represented in at least in one enriched pathway ConsensuspathDB-set.

Sample	24 h	48 h	72 h
OT1:	CHST2 $↑$ CRP $↑$ CTSL $↑$ CXCL8 $↑$ HES7 $↑$ HYDIN $↓$ ITIH3 $↑$ MAPK10 $↓$ MUC5AC $↓$ NDRG2 $↓$ RFX8 $↑$ RNA5S9 $↑$ RUNX1T1 $↓$ SCD $↑$ STC1 $↑$ VIPR1-AS1 $↓$ WARS $↑$	ADRA2C $↑$ AKR1C1 $↑$ CCL18 $↑$ CHCHD4 $↑$ CRP $↑$ CTSL $↑$ CYP3A5 $↓$ MMP14 $↑$ MUC5AC $↓$ OCEL1 $↑$ OLFM4 $↑$ REG4 $↓$ SCD $↑$ SERPINA1 $↑$ TEX41 $↓$ TMEM126A $↑$ TRDN-AS1 $↓$ TXNIP $↓$	ADRA2C $↑$ CCL18 $↑$ CH25H $↑$ CLGN $↑$ CRP $↑$ CTSL $↑$ HYOU1 $↑$ MMP14 $↑$ MUC5AC $↓$ OLFM4 $↑$ REG4 $↓$ SCD $↑$ SERPINB4 $↑$ TNNT2 $↓$ TXNIP $↓$ VIPR1-AS1 $↓$ WARS $↓$ ZBBX $↓$
OT5:	ABCC8 $↓$ ADM $↑$ ADRA2C $↑$ ALDH1A2 $↑$ CPA1 $↓$ CTSL $↑$ GAL $↑$ HMGCS2 $↓$ ICAM5 $↑$ IER3 $↑$ NDRG1 $↑$ NDRG2 $↓$ NOTUM $↑$ PLIN2 $↑$ PNLIPRP1 $↓$ PPP1R15A $↑$ SFRP1 $↓$ TTR $↓$	ABCC8 $↓$ CPA1 $↓$ CREB3L3 $↑$ DLG2 $↓$ IGHA2 $↓$ IGHM $↓$ IGKC $↓$ INHBB $↓$ MUC6 $↓$ NR4A1 $↓$ PNLIPRP1 $↓$ PPP1R1B $↓$ SCN7A $↓$ SLC30A8 $↓$ TCF4 $↓$ THBS1 $↓$	ABCC8 $↓$ ADM $↓$ ADRA2C $↑$ ALB $↑$ CAPN13 $↓$ CREB3L3 $↑$ CTSL $↑$ CXCL5 $↓$ DIAPH3 $↓$ FCGR3B $↓$ FOLR2 $↓$ GAL $↑$ ICAM5 $↑$ IGHM $↓$ ITIH3 $↓$ JCHAIN $↓$ MMP11 $↓$ PAX6 $↓$ PLIN2 $↑$ PNLIPRP1 $↓$ SLC28A2 $↓$ SPARCL1 $↓$
OT9:	ARC $↑$ CTSL $↑$ DUSP5 $↑$ F13A1 $↓$ FST $↓$ FZD10 $↑$ GJA1 $↑$ GRIA1 $↓$ HK2 $↑$ IGFBP1 $↑$ LIF $↑$ NOG $↑$ OSM $↑$ PLIN2 $↑$ PMAIP1 $↑$ PPP1R15A $↑$ PTGS2 $↑$ TBX3 $↑$ TGFBI $↑$ VEGFA $↑$	ANK3 $↓$ CTSL $↑$ FST $↑$ GJA1 $↑$ IER3 $↑$ IL33 $↑$ PLIN2 $↑$ PMAIP1 $↑$ PTGS2 $↑$ TGFBI $↑$ TXNIP $↓$ UGT2A1 $↓$ VEGFA $↑$	BRCA1 $↓$ CD44 $↑$ CFB $↑$ CNKSR2 $↓$ ELN $↓$ ENO1 $↑$ F13A1 $↓$ ITGA7 $↓$ MEF2C $↓$ MFAP5 $↓$ MT-CO1 $↓$ MT-CO2 $↓$ MT-CYB $↓$ MT-ND1 $↓$ MT-ND2 $↓$ MT-ND3 $↓$ MT-ND4 $↓$ MT-ND5 $↓$ MT-ND6 $↓$ MT-TC $↓$ MT-TL1 $↓$ MT-TM $↓$ MT-TQ $↓$ MT-TV $↓$ ORM1 $↑$ PAX6 $↑$ PNPLA7 $↓$ RPS4Y1 $↓$ ST3GAL6 $↑$ VEGFA $↑$
OT11:	No differentially expressed genes were found after 24 hours of culture.	A2M $↓$ ADRA2C $↑$ AMY2A $↓$ CCL21 $↓$ CPA1 $↓$ CPA2 $↓$ CRISP3 $↓$ CTGF $↓$ CTSL $↑$ CXCR4 $↓$ DUSP1 $↓$ EGR1 $↓$ FOS $↓$ FOXA3 $↑$ HAGHL $↑$ HLA-DQB2 $↓$ HYOU1 $↑$ IGHA1 $↓$ IGHA2 $↓$ IGHD $↓$ IGKC $↓$ JCHAIN $↓$ MUC6 $↓$ PLAU $↑$ PNLIP $↓$ SCD $↑$ SERPINA1 $↑$ SPARCL1 $↓$ STC1 $↑$ TRDN-AS1 $↑$ TSC22D3 $↓$ ZFP36 $↓$ ZNF331 $↓$	A2M $↓$ ADRA2C $↑$ CCL21 $↓$ CP $↑$ CRP $↑$ CTGF $↓$ CX3CR1 $↓$ EGR1 $↓$ F5 $↓$ FOLR2 $↓$ FOS $↓$ IGFBP1 $↑$ IGHA1 $↓$ IGHA2 $↓$ IGHD $↓$ IGHG1 $↓$ IGKC $↓$ IGLC1 $↓$ JCHAIN $↓$ MUC6 $↓$ NMU $↑$ RGS1 $↓$ SCD $↑$ SERPINA1 $↑$ SERPINB3 $↑$ SERPINB4 $↑$ SPARCL1 $↓$ TSC22D3 $↓$ ZFP36 $↓$
OT12:	COL21A1 $↓$ COL7A1 $↑$ CTSL $↑$ F3 $↑$ FOLR2 $↓$ GALNT5 $↑$ LAMC2 $↑$ MAPK10 $↓$ PNLIPRP1 PPY $↓$ THSD7B $↓$ VIP $↑$	None of the mapped entities (18 out of 20) were significantly over-represented in any pathway	CTSL $↑$ MMP14 $↑$ TXNIP $↓$