Table 4.
Probability of the top 3 significantly suggested pathways according to the hypergeometric test in different databases.
| p-value | Pathway | Database | Mapped genes | ||
|---|---|---|---|---|---|
| OT1 | 24 h | 0.000122 | IL-17 signaling pathway - Homo sapiens (human) | KEGG | MAPK10; MUC5AC; CXCL8 |
| 24 h | 0.000182 | Overview of nanoparticle effects | Wikipathways | CXCL8; CRP | |
| 24 h | 0.000431 | nfkb activation by nontypeable hemophilus influenzae | BioCarta | CXCL8; MUC5AC | |
| 48 h | 0.000724 | Collagen degradation | Reactome | MMP14; CTSL | |
| 48 h | 0.000784 | Innate Immune System | Reactome | CRP; CTSL; TXNIP; OLFM4; SERPINA1; MUC5AC | |
| 48 h | 0.00154 | Xenobiotics metabolism | EHMN | CYP3A5; AKR1C1 | |
| 72 h | 0.000724 | Collagen degradation | Reactome | MMP14; CTSL | |
| 72 h | 0.00392 | Phenytoin (Antiarrhythmic) Action Pathway | SMPDB | HYOU1; TNNT2 | |
| 72 h | 0.00548 | Innate Immune System | Reactome | CRP; CTSL; TXNIP; OLFM4; MUC5AC | |
| OT5 | 24 h | 1.12e-05 | Validated targets of C-MYC transcriptional repression | PID | HMGCS2; NDRG1; NDRG2; SFRP1 |
| 24 h | 0.000266 | HIF-1-alpha transcription factor network | PID | ADM; PLIN2; NDRG1 | |
| 24 h | 0.000877 | Sympathetic Nerve Pathway (Neuroeffector Junction) | PharmGKB | ADM; ADRA2C | |
| 48 h | 1.92e-05 | Inflammatory Response Pathway | Wikipathways | IGHA2; THBS1; IGHM | |
| 48 h | 0.0028 | Cocaine addiction - Homo sapiens (human) | KEGG | PPP1R1B; CREB3L3 | |
| 48 h | 0.00326 | Peptide hormone metabolism | Reactome | INHBB; SLC30A8 | |
| 72 h | 0.00153 | Sympathetic Nerve Pathway (Neuroeffector Junction) | PharmGKB | ADM; ADRA2C | |
| 72 h | 0.00235 | Degradation of the extracellular matrix | Reactome | MMP11; CAPN13; CTSL | |
| 72 h | 0.0026 | Plasma lipoprotein remodeling | Reactome | CREB3L3; ALB | |
| OT9 | 24 h | 3.07e-06 | Photodynamic therapy-induced HIF-1 survival signaling | Wikipathways | PTGS2; IGFBP1; PMAIP1; VEGFA |
| 24 h | 7.54e-06 | Interleukin-4 and Interleukin-13 signaling | Wikipathways | PTGS2; OSM; VEGFA; F13A1; LIF | |
| 24 h | 3.54e-05 | HIF-1-alpha transcription factor network | PID | PLIN2; IGFBP1; HK2; VEGFA | |
| 48 h | 4.31e-05 | Photodynamic therapy-induced HIF-1 survival signaling | Wikipathways | PTGS2; PMAIP1; VEGFA | |
| 48 h | 0.000368 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis | Wikipathways | PTGS2; VEGFA | |
| 48 h | 0.000661 | S1P1 pathway | PID | PTGS2; VEGFA | |
| 72 h | 2.37e-11 | Respiratory electron transport | Reactome | MT-CO2; MT-CO1; MT-CYB; … | |
| 72 h | 3.11e-11 | Electron Transport Chain (OXPHOS system in mitochondria) | Wikipathways | MT-ND6; MT-ND5; MT-ND4;… | |
| 72 h | 1.56e-10 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling | Reactome | MT-CO2; MT-CO1; MT-CYB; … | |
| OT11 | 48 h | 2.48e-05 | AP-1 transcription factor network | PID | FOS; DUSP1; EGR1; PLAU |
| 48 h | 8.59e-05 | Pancreatic secretion - Homo sapiens (human) | KEGG | AMY2A; PNLIP; CPA1; CPA2 | |
| 48 h | 0.000126 | ErbB1 downstream signaling | PID | FOS; ZFP36; EGR1; DUSP1 | |
| 72 h | 1.33e-05 | Post-translational protein phosphorylation | Reactome | SPARCL1; CP; F5; SERPINA1; IGFBP1 | |
| 72 h | 2.69e-05 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | Reactome | SPARCL1; CP; F5; SERPINA1; IGFBP1 | |
| 72 h | 0.000316 | IL6-mediated signaling events | PID | CRP; FOS; A2M | |
| OT12 | 24 h | 4.01e-06 | Collagen formation | Reactome | LAMC2; COL7A1; CTSL; COL21A1 |
| 24 h | 2.56e-05 | Assembly of collagen fibrils and other multimeric structures | Reactome | LAMC2; CTSL; COL7A1 | |
| 24 h | 2.97e-05 | Anchoring fibril formation | Reactome | COL7A1; LAMC2 | |
| 72 h | 0.000147 | Collagen degradation | Reactome | MMP14; CTSL | |
| 72 h | 0.00132 | Degradation of the extracellular matrix | Reactome | MMP14; CTSL | |
| 72 h | 0.0065 | VEGFA-VEGFR2 Signaling Pathway | Wikipathways | MMP14; TXNIP |