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. 2020 Jun 3;10:9049. doi: 10.1038/s41598-020-65685-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of motoneuron firing frequency-current relationships in hG93A-SOD1 and wild-type mice. (A,B) Repetitive firing in response to the injected current ramps in a representative wild-type motoneuron (A) and an hG93A-SOD1 motoneuron (B). The corresponding current amplitude at first spike onset and last spike are defined as Ion and Ioff and the difference as ΔI. C, The instantaneous frequency was calculated from (A) and (B) and plotted against the corresponding current intensity to generate the F-I relationships of the wild-type (red trace) and the hG93A-SOD1 (green trace), respectively. The red arrow in (B) indicates the onset of a PIC. The ascending and descending phases of the F-I relationships were then fitted with a linear equation to obtain the slopes, which are reported in Table 2 and used as a metric for excitability.