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. 2020 Jun 3;10:9049. doi: 10.1038/s41598-020-65685-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of persistent inward currents (PICs) in wild-type and hG93A-SOD1 motoneurons. A and C, PICs induced by slow, voltage bi-ramps (20 mV/s, from −80 mV to +10 mV) are indicated by the red arrows. The hG93A-SOD1 motoneurons (C) showed significantly larger PICs than the wild-types (A). The current response was then subtracted by leak current calculated before PIC happened as shown by linear fitting line, the black solid line in inlet of (C). B and D, for wild-type (B) and hG93A-SOD1 (D) received PF-4708671, they showed similar PIC amplitude as in (A). The average amplitudes of PIC of wild-type and hG93A-SOD1 were reported in Table 2.