Table 2.
Electrical properties of motoneurons.
| WT (N=25) | mSOD1 (N=22) | WT+PF (N=21) | mSOD1+PF (N = 24) | ||
|---|---|---|---|---|---|
| Non-hypoexcitable (N = 20) | Hypoexcitable (N = 4) | ||||
| Gin (nS) | 24 ± 10 | 32 ± 10 **(WT) | 22 ± 10 | 24 ± 8 **(mSOD1) | 29 ± 10 |
| RMP (mV) | −59 ± 4 | −60 ± 5 | −58 ± 5 | −60 ± 6 | −59 ± 3 |
| Ion (pA) | 445 ± 247 | 466 ± 346 | 417 ± 232 | 468 ± 307 | — |
| Ioff (pA) | 508 ± 291 | 521 ± 382 | 511 ± 280 | 547 ± 352 | — |
| ΔI (pA) | 63 ± 109 | 55 ± 97 | 94 ± 137 | 79 ± 152 | — |
| F-IAsd (Hz/nA) | 34 ± 18 | 36 ± 23 | 37 ± 25 | 38 ± 27 | — |
| F-IDsd (Hz/nA) | 36 ± 19 | 39 ± 26 | 39 ± 26 | 41 ± 25 | — |
| AP overshoot (mV) | 29 ± 10 | 30 ± 11 | 30 ± 9 | 29 ± 10 | 27 ± 6 |
| Voltage threshold (mV) | −30 ± 6 | −29 ± 5 | −30 ± 7 | −28 ± 6 | −28 ± 4 |
| Capacitance (pF) | 332 ± 103 | 338 ± 112 | 334 ± 107 | 331 ± 114 | 345 ± 64 |
| PIC | |||||
| Amplitude (pA) | −200 ± 73 | −357 ± 111 **(WT) | −202 ± 91 | −229 ± 79 **(mSOD1) | −87 ± 29 **(mSOD1+PF) |
| Peak voltage(mV) | −21 ± 6 | −21 ± 7 | −22 ± 9 | −23 ± 6 | −27 ± 5 |
| Onset voltage(mV) | −46 ± 7 | −45 ± 6 | −47 ± 8 | −47 ± 6 | −47 ± 4 |
P-values were calculated by Turkey's test in post-hoc analysis in comparison to group as specified (**P<0.01). Wild-type, WT; hG93A-SOD1, mSOD1; PF-4708671, PF; input conductance, Gin; persistent inward current, PIC; Ion, onset current in F-I relationship; Ioff, offset current in F-I relationship; ΔI, difference between Ion and Ioff; F-IAsd, slope of linear fit in ascending phase of F-I relationship; F-IDsd, slope of linear fit in descending phase of F-I relationship.