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. 2020 Jun 3;20:212. doi: 10.1186/s12935-020-01305-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — NaB accelerated gp130 degradation by increasing the level of TRAF5. a TRAF5 transcription analyzed by the GEPIA web tool. b, c Western blotting of TRAF5 protein levels in cells treated with NaB (5 mM) for 24 h. d Co-immunoprecipitation assay of gp130 and TRAF5 in HT-29 cells treated with 5 mM NaB for 24 h. e–g Rescue experiments of HT-29 cells transfected with TRAF5 siRNA. h A schematic diagram of the mechanism