Table 3.
Pearson correlation coefficients (r) between functional connectivity (FC) and disease severity represented by MMSE. Correlations were estimated for the entire population (cohorts 1 and 2) and the AD subjects only. Bold r values indicate a significant (p < 0.05) correlation
| FC measure versus MMSE | All subjects (n = 809) | AD only (n = 410) | ||
|---|---|---|---|---|
| r | p-value | r | p-value | |
| Theta (4–8 Hz) | ||||
| iCoh | − 0.13 | 1.41 × 10−4 | − 0.06 | 0.23 |
| PLI | − 0.13 | 2.79 × 10−4 | − 0.06 | 0.23 |
| wPLI | − 0.13 | 1.71 × 10−4 | − 0.06 | 0.21 |
| Alpha (8–13 Hz) | ||||
| AEC-c | 0.21 | 3.2 × 10−9 | 0.14 | 0.0054 |
| AEC | 0.35 | 6.1 × 10−25 | 0.14 | 0.0065 |
| Coh | 0.27 | 6.4 × 10−15 | 0.04 | 0.40 |
| PLV | 0.23 | 7.3 × 10−11 | 0.08 | 0.13 |
| Beta (13–30 Hz) | ||||
| AEC-c | 0.21 | 1.8 × 10−9 | 0.08 | 0.12 |
| AEC | 0.26 | 1.0 × 10−13 | 0.13 | 0.0073 |
| Coh | 0.22 | 3.1 × 10−10 | 0.12 | 0.015 |