Table 3.
Nuclear magnetic resonance (NMR) observed serum metabolites with intensity differences associated with different AFP for hepatocellular carcinoma
| Metabolites | AFP < 15 ng/ml | AFP ≥ 15 ng/ml | P valuea |
|---|---|---|---|
| Investigation cohort (n= 35) | |||
| Glycine | 26.128 ± 2.83 | 18.627 ± 1.09 | 0.006 |
| O-Acetylcarnitine | 0.600 ± 0.08 | 0.374 ± 0.11 | 0.025 |
| Histidine | 6.597 ± 0.36 | 5.532 ± 0.37 | 0.062 |
| Ornithine | 9.263 ± 1.05 | 7.065 ± 0.58 | 0.073 |
| Validation cohort (n= 22) | |||
| Glycine | 26.810 ± 1.33 | 27.195 ± 2.19 | 0.752 |
| O-Acetylcarnitine | 0.958 ± 0.09 | 0.687 ± 0.08 | 0.032 |
| Histidine | 7.303 ± 0.32 | 6.070 ± 0.55 | 0.153 |
| Ornithine | 10.504 ± 0.86 | 9.061 ± 0.75 | 0.215 |
Metabolites were expressed as mean ± SE in arbitrary units
aStudent’s t test