Table 3. Twelve-Item Short-Form Health Survey Mental Component Summary Scores Comparison in Aspirin and Placebo Groups.
| Year | Patients, No. | Mental component score | |||
|---|---|---|---|---|---|
| Mean (SD) | Differential changea (95% CI)b | Effect size (Cohen d) | |||
| Aspirin group | Placebo group | ||||
| Baseline | 19 106 | 55.8 (7.1) | 55.6 (7.2) | NA | NA |
| 1 | 18 088 | 55.5 (7.4) | 55.6 (7.1) | –0.3 (–0.5 to 0.0) | –0.03 |
| 2 | 17 350 | 55.7 (7.3) | 55.6 (7.4) | 0.0 (–0.2 to 0.2) | 0.00 |
| 3 | 15 112 | 55.6 (7.5) | 55.6 (7.3) | –0.1 (–0.4 to 0.1) | –0.01 |
| 4 | 11 413 | 55.6 (7.5) | 55.7 (7.4) | –0.2 (–0.5 to 0.0) | –0.02 |
| 5 | 7209 | 55.2 (7.5) | 55.4 (7.5) | –0.3 (–0.7 to 0.0) | –0.04 |
| 6 | 7209 | 55.5 (7.6) | 55.4 (7.2) | –0.2 (–0.7 to 0.2) | –0.07 |
Abbreviation: NA, not applicable.
a
Differential change from baseline at follow-ups (aspirin vs placebo) was estimated from a 2-way interaction of intervention allocation and follow-up annual visit from a generalized estimating equation model; the references were the baseline measurement and the placebo group.
b
P value and test statistic for intervention by follow-up annual visit interaction test: χ26, 9.61; P = .14.