Figure 4.

Defective shear-dependent thrombus formation in Cotl1-deficient mice can be rescued by exogenous addition of leukotriene B₄. (A–C) Assessment of platelet adhesion (A and B) and aggregate formation in heparinized blood (A and C) on Horm collagen (70 μg mL⁻¹) under flow (1700 s⁻¹). WT and Cotl1^−/− samples were either left untreated or were pre-incubated for 5 minutes (min) with LTB₄ [0.25 nM]. Images are representatives of at least 12 mice per group. Values are mean±standard deviation. Scale bar, 50 μm. *P<0.1; **P<0.01.