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. 2020 Apr 30;105(6):1478–1483. doi: 10.3324/haematol.2019.243063

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Figure 2. — Putative immunoregulatory properties of CD71⁺ erythroid cells. The proposed model hypothesizes that CD71⁺ erythroid cells via cell-cell interactions (VISTA:?, PD-1:PDL1/PDL-2 and Galectins) or via soluble factors (e.g. TGF-β, Arginase-2, ROS and Galectins) suppress or modulate the functionality of different immune cells. PD-1: programmed cell death protein 1; PDL: programmed death ligand; VISTA: V-domain Ig suppressor of T-cell activation; TGF-β: transforming growth factor-β. ROS: reactive oxygen species; DC: dendritic cells; CEC: CD71⁺ erythroid cells.