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. 2019 Sep 19;105(6):1593–1603. doi: 10.3324/haematol.2019.220160

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Figure 6. — Evidence of T-cell receptor repertoire restriction in follicular lymphoma. (A) The clonality of the T-cell receptors (TCR) in intrafollicular areas was higher than in the interfollicular compartment in all cases examined, horizontal bars represent mean of all samples, median clonality 0.062 versus 0.049 respectively, Mann Whitney, P=0.0317. (B) Summary of TCR repertoire data showing the proportion of the total population accounted for by high frequency clones in the follicular and interfollicular regions of follicular lymphoma lymph nodes. In each case, the more frequent clones predominate in the follicular regions compared to the interfollicular areas. (C) The level of overlap of clonotypes between follicular and interfollicular compartments for all clones in paired samples (all clones) and for the 100 most frequent clones (top 100 clones). Horizontal bars represent the mean overlap (0.125 for all clones and 0.22 for top 100 clones)