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. 2019 Sep 5;105(6):1582–1592. doi: 10.3324/haematol.2019.226647

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Figure 2. — Nodal peripheral T-cell lymphomas (PTCL) with a double T_FH/Th2 phenotype and a molecular Th2 signature. (A) Diffuse proliferation of large pleomorphic cells; this case would be classified as T_FH PTCL according to the World Health Organization 2017, based on the expression of 2 T_FH markers, i.e. PD1 (B) and BCL6 (C), but disclosed strong nuclear staining for GATA3 in virtually all tumor cells (D) and, although less uniform, FOXP3 (E). Few tumor cells also expressed CD30 (F). Reverse transcriptase-multiplex ligation-dependent probe amplification (RT-MLPA) profile showed a Th2 signature and classified in the Th2 class by the support vector machine (SVM).