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. 2020 Apr 9;21(6):e49708. doi: 10.15252/embr.201949708

Figure EV5. P‐IκBα is lost in damaged areas, where NF‐κB pathway is active, and accumulated in regenerating crypts.

Figure EV5

  • A
    IHC analysis of P‐IκBα (S36) in the colonic tissue of control and DSS‐treated mice including acute damaged (AD) areas and recovery (R) areas.
  • B
    IF analysis of the NF‐κB subunits p65/RelA and c‐Rel in areas of acute damage and recovery. Asterisks indicate the presence of nuclear p65 in acute damage areas adjacent to the recovery region. The pictures show acute damaged (AD) areas and recovery (R) areas.
  • C, D
    Graph indicating the reduced weight (A) and representative image of the skin defects (see arrowhead) (D) observed in the 2‐month‐old IκBα KO mice. Bars represent mean values ± standard error of the mean (s.e.m.).
Data information: Scale bars, in A and B, 50 μm.