Table 2.

Effect of Grewia ferruginea Methanol Extract on Gastrointestinal Transit in Loperamide-Induced Constipated Mice.*

Group	Dose	Distance traveled by charcoal (cm)	Gastrointestinal transit ratio (%)
Group 1 (2% Tween 80)	10 mL/kg	46.0 ± 1.2	74.68 ± 1.31
Group 2 (2% Tween 80)	10 mL/kg	38.1 ± 1.2	59.98 ± 1.71
Group 3 (extract)	100 mg/kg	42.6 ± 2.3	65.01 ± 2.27
Group 4 (extract)	200 mg/kg	44.6 ± 1.7	74.29 ± 1.31b2
Group 5 (extract)	400 mg/kg	47.4 ± 2.1b1	80.74 ± 3.10b3c3
Group 6 (bisacodyl)	0.25 mg/kg	60.1 ± 2.8a3b3c3d3e2	89.97 ± 3.07a3b3c3d3

* Results expressed as mean ± SEM (n = 5). ¹ P < .05, ² P < .01, ³ P < .001, a: compared to group 1, b: compared to group 2, c: compared to group 3, d: compared to group 4, e: compared to group 5. Group 1 and group 2 animals are normal and constipated controls, respectively, and treated groups are all constipated.