Table 1.
Randomized clinical trials of contrast-rebalanced binocular games.
| Study | Game | Lines improved |
Age | >7 years | No prior patching |
Not orthotropic |
|---|---|---|---|---|---|---|
| Birch et al (2019)a Kelly et al (2016)b |
Dig Rush | 1.8 | 6.8 y | 25% | 42% | 21% 1-4pd |
| Holmes et al. (2016)c | Tetris | 1.1 | 8.4 y | 77% | 24% | 26% 1-9 and ≥10pd |
| PEDIG, et al. (2019)d | Dig Rush | 0.5 | 9.6 y | 100% | 6% | 32% 1-9 and ≥10pd |
| Manh et al. (2018)e | Tetris | 0.7 | 14.3 y | 100% | 23% | 38% 1-9 and ≥10pd |
| Gao et al. (2018)f | Tetris | 0.1 | 22 y | 100% | 20% | 55% 1-9 and ≥10pd |
y = years old; pd = prism diopters
Current study
Kelly KR, Jost RM, Dao L, et al. Binocular Ipad Game Vs Patching for Treatment of Amblyopia in Children: A Randomized Clinical Trial. Pediatric Eye Disease Investigator Group. JAMA Ophthalmol 2016;134:1402-8.
Holmes JM, Manh VM, Lazar EL, et al. Effect of a Binocular IPad Game vs. Part-Time Patching in Children Aged 5 to 12 Years with Amblyopia: A Randomized Clinical Trial. Pediatric Eye Disease Investigator Group. JAMA Ophthalmol 2016;134:1391-400.
Pediatric Eye Disease Investigator Group, Holmes JM, Manny RE, et al. A Randomized Trial of Binocular Dig Rush Game Treatment for Amblyopia in Children Aged 7 to 12 Years. Ophthalmology 2019;126:456-66.
Manh VM, Holmes JM, Lazar EL, et al. A Randomized Trial of a Binocular IPad Game versus Part-Time Patching in Children Aged 13 to 16 Years with Amblyopia. Pediatric Eye Disease Investigator Group. Am J Ophthalmol 2018;186:104-15.
Gao TY, Guo CX, Babu RJ, et al. Effectiveness of a Binocular Video Game vs. Placebo Video Game for Improving Visual Functions in Older Children, Teenagers, and Adults with Amblyopia: A Randomized Clinical Trial. BRAVO Study Team. JAMA Ophthalmol 2018;136:172-81.