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. 2020 Apr 15;20(1):335–342. doi: 10.3892/etm.2020.8668

Figure 3.

Figure 3

GA maintains the mitochondrial membrane potential potentially via decreasing mitochondrial ROS accumulation. (A) JC-1 staining was performed to investigate the effect of GA on the mitochondrial membrane potential. Multi-aggregates are stained red and mono-aggregates are stained green. Following treatment with 100 µM GA, 10 µM NAC or 1 µM MitoQ10, (B) ATP synthesis, (C) mtDNA copy number and (D) mtDNA transcriptional activity were assessed. *P<0.05 vs. normoxia group. #P<0.05 vs. H/R + mock group. GA, glycyrrhizic acid; ROS, reactive oxygen species; NAC, N-acetylcysteine; mtDNA, mitochondrial DNA; H/R, hypoxia/reoxygenation; TIM, Rho guanine nucleotide exchange factor 5; COXI, mitochondrially encoded cytochrome c oxidase I; ND1, mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1.