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. 2020 Apr 23;20(1):512–520. doi: 10.3892/etm.2020.8679

Figure 4.

Figure 4

Changes in the transcription of genes involved in Staphylococcus aureus colonization in response to NPWT. (A-C) NPWT resulted in significant upregulation of tagO, fnbA and isdA levels compared with untreated wounds throughout the time course. (D) RNAIII levels in the NPWT group were downregulated relative to the control group. Data of both groups were presented as the fold-changes in gene expression relative to the inoculum, which was used as the calibrator with a value of 1. *P<0.05, **P<0.01 and ***P<0.001 vs. untreated control. n=10 wounds/group. NPWT, negative pressure wound therapy. tagO, UDP-phosphate N-acetylglucosaminyl 1-phosphate transferase; fnbA, fibronectin-binding protein A; isdA, iron-regulated surface determinant A.