Table 2. Correlation of the PI3K/AKT/mTOR mRNA expression with OS in different clinical stage of ccRCC patients (K-M plotter, n = 530).

Gene	Stage	na	HR (95% CI)	P- value
PTEN	I	265	0.46 (0.25–0.85)	0.011
	II	57	3.28 (1.04–10.37)	0.034
	III	123	0.44 (0.25–0.79)	0.005
	IV	82	0.51 (0.30–0.87)	0.012
PIK3CA	I	265	0.48 (0.26–0.88)	0.016
	II	57	2.08 (0.67–6.48)	0.200
	III	123	0.51 (0.29–0.89)	0.017
	IV	82	0.61 (0.37–1.00)	0.049
PIK3CB	I	265	0.43 (0.23–0.81)	0.007
	II	57	2.14 (0.47–9.73)	0.310
	III	123	0.40 (0.22–0.70)	0.001
	IV	82	0.41 (0.25–0.67)	<0.001
PIK3CD	I	265	1.41 (0.74–2.70)	0.300
	II	57	2.25 (0.69–7.33)	0.170
	III	123	0.55 (0.31–0.96)	0.033
	IV	82	2.42 (1.25–4.68)	0.007
PIK3CG	I	265	0.53 (0.28–1.00)	0.045
	II	57	0.29 (0.08–1.00)	0.046
	III	123	0.31 (0.17–0.54)	<0.001
	IV	82	0.59 (0.34–1.03)	0.062
AKT1	I	265	0.44 (0.24–0.80)	0.006
	II	57	3.00 (0.98–9.20)	0.044
	III	123	2.15 (1.14–4.07)	0.015
	IV	82	1.28 (0.78–2.10)	0.330
AKT2	I	265	1.65 (0.91–2.99)	0.093
	II	57	2.22 (0.76–7.14)	0.130
	III	123	1.58 (0.90–2.78)	0.110
	IV	82	1.61 (0.96–2.68)	0.067
AKT3	I	265	0.56 (0.31–1.02)	0.054
	II	57	0.43 (0.09–1.95)	0.260
	III	123	0.45 (0.25–0.81)	0.006
	IV	82	0.50 (0.27–0.94)	0.029
mTOR	I	265	0.30 (0.12–0.77)	0.008
	II	57	0.24 (0.06–0.86)	0.018
	III	123	0.58 (0.33–1.02)	0.053
	IV	82	1.36 (0.82–2.26)	0.240

Notes.

^aThe total number was 527, because there were missing expression values and/ or incomplete survival data.