Table 3. Correlation of the PI3K/AKT/mTOR mRNA expression with OS in different sex of ccRCC patients (K-M plotter, n = 530).

Gene	Sex	n	HR (95% CI)	P-value
PTEN	female	186	0.35 (0.21–0.59)	<0.001
	male	344	0.53 (0.36–0.77)	<0. 001
PIK3CA	female	186	0.27 (0.15–0.51)	<0. 001
	male	344	0.57 (0.39–0.82)	0.003
PIK3CB	female	186	0.45 (0.27–0.76)	0.002
	male	344	0.48 (0.33–0.70)	<0.001
PIK3CD	female	186	0.57 (0.34–0.97)	0.037
	male	344	1.81 (1.22–2.68)	0.003
PIK3CG	female	186	0.49 (0.30–0.82)	0.006
	male	344	0.68 (0.47–0.99)	0.044
AKT1	female	186	0.51 (0.31–0.85)	0.008
	male	344	0.76 (0.49–1.17)	0.210
AKT2	female	186	0.76 (0.46–1.25)	0.270
	male	344	1.71 (1.15–2.55)	0.007
AKT3	female	186	0.32 (0.20–0.54)	<0.001
	male	344	0.48 (0.31–0.72)	<0.001
mTOR	female	186	0.27 (0.14–0.52)	<0.001
	male	344	0.78 (0.54–1.14)	0.200