Figure 5.

Application strategy for sprayable pressure-sensitive tissue adhesive (PSTA) and immune response toward PSTA components. PSTA can be sprayed directly onto a biopsy site (Ai), forming a thin coherent layer in approximately 1 min (Aii). A cardiac patch can be secured to the biopsy site by applying pressure (Aiii). During patch removal, the adhesive produces a strong bond (Aiv) with high energy dissipation through material stretching and cracking prior to failure (Av). (B) Frequency of fibrotic adhesions to the fat pads and implant fragmentation for polymers implanted in the intraperitoneal space of a mouse model, at 3 and 10 days postsurgery. Serum levels of tumor necrosis factor-α (TNF-α) (C) and interferon-γ (IFN-γ) (D) for the same model.