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. 2020 May 28;10:680. doi: 10.3389/fonc.2020.00680

Table 1.

Diagnostic performance of seven-way classifiers and radiologists in the validation set.

Value (95%CI) McNemar's P-valuea Delong P-value
Model A Model B Reader consensus Model A vs. Reader Model A vs. Model B
Cyst
 AUC 0.986 (0.960, 1.000) 0.970 (0.932, 1.000) 0.147
 Sensitivity, % 89.5 (75.2, 97.1) 89.5 (75.2, 97.1) 94.7 (82.3, 99.4) 0.688
 Specificity, % 96.9 (93.0, 99.0) 96.9 (93.0, 99.0) 98.2 (94.7, 99.6) 0.727
Hemangioma
  AUC 0.944 (0.897, 0.991) 0.936 (0.886, 0.986) 0.66
Sensitivity, % 82.6 (68.6, 92.2) 87.0 (73.7, 95.1) 89.1 (76.4, 96.4) 0.508
 Specificity, % 95.5 (90.9, 98.2) 93.6 (88.5, 96.9) 98.1 (94.5, 99.6) 0.344
FNH
 AUC 0.987 (0.934, 1.000) 0.936 (0.824, 1) 0.102
 Sensitivity, % 100 (66.4, 100) 66.7 (29.9, 92.5) 88.9 (51.8, 99.7) 1.000
 Specificity, % 95.8 (92.0, 98.2) 94.8 (90.63, 97.5) 100 (98.1, 100) 0.008
Benign nodules
 AUC 0.914 (0.787, 1.000) 0.865 (0.711, 1.000) 0.139
 Sensitivity, % 77.8 (40.0, 97.2) 66.7 (29.9, 92.5) 55.6 (21.2, 86.3) 0.500
 Specificity, % 99.5 (97.1, 100) 99.5 (97.1, 100) 98.4 (95.5, 99.7) 0.625
HCC
 AUC 0.925 (0.871, 0.978) 0.879 (0.813, 0.9452) 0.137
 Sensitivity, % 87.2 (74.3, 95.2) 74.5 (59.7, 86.1) 87.2 (74.3, 95.2) 1.000
 Specificity, % 91.6 (86.0, 95.4) 86.4 (79.9, 91.4) 94.8 (90.0, 97.7) 0.267
Metastatic malignancy
 AUC 0.897 (0.828, 0.966) 0.841 (0.758, 0.923) 0.039
 Sensitivity, % 59.6 (42.1, 75.3) 40.5 (24.8, 57.9) 89.2 (74.6, 97.0) 0.003
 Specificity, % 97.6 (93.9, 99.3) 97.0 (93.0, 99.0) 97.6 (93.9, 99.3) 1.000
Primary malignancy except HCC
 AUC 0.899 (0.793, 1.000) 0.892 (0.783, 1.000) 0.844
 Sensitivity, % 53.3 (26.6, 78.7) 46.7 (21.3, 73.4) 60.0 (32.3, 83.7) 0.688
 Specificity, % 97.9 (94.6, 99.4) 96.8 (93.1, 98.8) 96.2 (92.4, 98.5) 0.727
a

P-value was calculated between Model A (seven-classification) vs. Reader consensus using the McNemar's test.