Table 3.
Diagnostic performance of three-way classifiers and radiologists in the malignancy validation set.
| Value (95%CI) | McNemar's P-Valuea | Delong P-Value | |||||
|---|---|---|---|---|---|---|---|
| Model E | Model F | Model G | Reader consensus | Model G vs. Reader | Model E vs. Model G | Model F vs. Model G | |
| HCC | |||||||
| AUC | 0.879 (0.808, 0.949) | 0.972 (0.938, 1.000) | 0.951 (0.906, 0.997) | 0.002 | 0.792 | ||
| Sensitivity, % | 93.6 (82.5, 98.7) | 95.7 (85.5, 99.5) | 95.7 (85.5, 99.5) | 89.1 (76.4, 96.4) | 0.289 | ||
| Specificity, % | 67.3 (52.9, 79.7) | 96.2 (86.8, 99.5) | 90.4 (79.0, 96.8) | 90.4 (79.0, 96.8) | 0.063 | ||
| Metastatic malignancy | |||||||
| AUC | 0.814 (0.722, 0.907) | 0.980 (0.947, 1.000) | 0.985 (0.958, 1.000) | 0.0002 | 0.403 | ||
| Sensitivity, % | 59.5 (42.1, 75.3) | 100 (90.5, 100) | 94.6 (81.8, 99.3) | 89.2 (74.6, 97.0) | 0.688 | ||
| Specificity, % | 93.6 (84.3, 98.2) | 96.8 (88.8, 99.6) | 100 (94.2, 100) | 95.1 (86.3, 99.0) | 1.000 | ||
| Primary malignancy except HCC | |||||||
| AUC | 0.761 (0.613, 0.909) | 0.989 (0.951, 1.000) | 0.905 (0.801, 1.000) | 0.008 | 0.081 | ||
| Sensitivity, % | 53.3 (26.6, 78.7) | 86.7 (59.5, 98.3) | 73.3 (44.,9 92.2) | 60.0 (32.3, 83.7) | 0.688 | ||
| Specificity, % | 95.2 (88.3, 98.7) | 100 (95.7, 100) | 96.4 (89.9, 99.3) | 91.6 (83.4, 96.5) | 0.250 | ||
a
P value was calculated between Model G (three-sequence images + clinical data) vs. Reader consensus using the McNemar's test.