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. 2020 Jun 4;15(6):e0234212. doi: 10.1371/journal.pone.0234212

Table 5. Compliance and outcome of cases of possible serious bacterial infection who treated with simplified treatment and who accepted referral and were treated at district hospital.

Parameters All PSBI cases Fast Breathing 7–59 days Fast Breathing 0–6 days Clinical Severe Infection 0–59 days Critical Illness 0–59 days
A. Compliance of treatment N = 959 n/m (%) N = 147 n/m (%) N = 34 n/m (%) N = 685 n/m (%) N = 93 n/m (%)
Number of oral amoxicillin doses
14 Doses
517/959 (53.9) 105/147 (71.4) 31/34 (91.2) 333/685 (48.6) 48/93 (51.6)
10–13 Doses 293/959 (30.6) 41/147 (27.9) 3/34 (8.8) 228/685 (33.3) 21/93 (22.6)
6–9 Doses 10/959 (1.0) 1/147 (0.7) - 9/685 (1.3) -
5 or less Doses 17/959 (1.8) - - 9/685 (1.3) 8/93 (8.6)
Other oral antibiotics received§ 122/959 (12.7) - - 106/685 (15.5) 16/93 (17.2)
Injection gentamicin received N = 812 n/m (%) NA N = 34 n/m (%) N = 685 n/m (%) N = 93 n/m (%)
7 injections 132/812 (16.3) NA 16/34 (47.1) 80/685 (11.7) 36/93 (38.7)
5–6 injections 217/812 (26.7) NA 10/34 (29.4) 192/685 (28.0) 15/9 (16.1)
3–4 injections 90/812 (11.1) NA 5/34 (14.7) 80/685 (11.7) 5/93 (5.4)
1–2 injections 73/812 (9.0) NA - 52/685 (7.6) 21/93 (22.6)
Other injectable antibiotic (amikacin) received 300/812 (36.9) NA 3/34 (8.8) 281/685 (41.0) 16/93 (17.2)
B. Outcome for those who accepted simplified treatment (based on respondent’s perception) N = 959 n/m (%) N = 147 n/m (%) N = 34 n/m (%) N = 685 n/m (%) N = 93 n/m (%)
    Infants declared as ‘Treatment success’ 886/959 (92.4) 140/147 (95.2) 34/34 (100) 645/685 (94.2) 67/93 (72.0)
    Infants declared as ‘Treatment failure’ 73/959 (7.6) 7/147 (4.8) 0/34 (0) 40/685 (5.8) 26/93 (28.0)
Reason for treatment failure N = 73 n/m (%) N = 7 n/m (%) N = 0 n/m (%) N = 40 n/m (%) N = 26 n/m (%)
    Left treatment 45/73 (62.5) 7/7 (100) 0/0 (0) 30/40 (75) 8/26 (30.8)
    Persistence of presenting sign on day 8 1/73 (1.4) 0/7 (0) 0/0 (0) 0/40 (0) 1/26 (3.8)
    Deaths 25/73 (34.2) 0/7 (0) 0/0 (0) 09/40 (22.5) 16/26 (61.5)
    Outcome unknown 2/73 (2.8) 0/7 (0) 0/0 (0) 01/40 (2.6) 1/26 (3.8)
C. Outcome of the illness on Day 7 of those who accepted referral and were treated at district hospital N = 88 n/m (%) N = 1 n/m (%) N = 1 n/m (%) N = 50 n/m (%) N = 36 n/m (%)
    Cured 67/88 (76.1) 1/1 (100) 1/1 (100) 45/50 (90) 20/36 (55.6)
    Better 7/88 (8.0) 0/1 (0) 0/1 (0) 02/50 (4) 05/36 (13.9)
    Still sick 2/88 (2.3) 0/1 (0) 0/1 (0) 0/50 (0) 02/36 (5.6)
    Same 1/8 (1.1) 0/1 (0) 0/1 (0) 0/50 (0) 01/36 (2.8)
    Outcome unknown 0/88 (0) 0/1 (0) 0/1 (0) 03/50 (6) 0/36 (0)
    Deaths 11/88 (12.5) 0/1 (0) 0/1 (0) 03/50 (6) 08/36 (22)

¶ Excluding cases of fast breathing in ages 7–59 days.

§ Oral amoxicillin was unavailable

∞ Injection gentamicin was unavailable