Fig 1. Exploration of the connected interface (S100A1/MDM2) section in S100A1.

(a) The ¹H−¹⁵N HSQC spectra overlay of free ¹⁵N S100A1 (red) and in complex with unlabelled MDM2 (blue). Cross-peaks displaying variation in their magnitude are highlighted in yellow. Residues were assigned as published earlier. [61] (b) A picture illustration of the S100A1 protein with residues demonstrating a change in cross-peak signals portrayed by the red color.