Table 2.
DTR, CR, and ECR episodes and site-specific DOT by species*
| DTR episodes | DTR DOT | CR episodes | CR DOT | ECR episodes | ECR DOT | |
|---|---|---|---|---|---|---|
| Pseudomonas aeruginosa | ||||||
| Urinary (5 DOT) | 127 | 635 | 715 | 3575 | 244 | 1220 |
| Intra-abdominal (7 DOT) | 17 | 119 | 74 | 518 | 16 | 112 |
| Lower respiratory (8 DOT) | 278 | 2224 | 1028 | 8224 | 396 | 3168 |
| Skin and soft tissue (5 DOT) | 48 | 240 | 233 | 1165 | 125 | 625 |
| Other (5 DOT) | 13 | 65 | 74 | 370 | 31 | 155 |
| Primary bloodstream (14 DOT) | 33 | 462 | 137 | 1918 | 38 | 532 |
| Secondary bloodstream (14 DOT) | 6 | 84 | 20 | 280 | 6 | 84 |
| Total | 522 | 3829 | 2281 | 16 050 | 856 | 5896 |
| DOT per 10 000 encounters | .. | 12·8 | .. | 53·6 | .. | 19·7 |
| Acinetobacter baumannii complex | ||||||
| Urinary (5 DOT) | 76 | 380 | 39 | 195 | 80 | 400 |
| Intra-abdominal (7 DOT) | 11 | 77 | 5 | 35 | 9 | 63 |
| Lower respiratory (8 DOT) | 173 | 1384 | 102 | 816 | 183 | 1464 |
| Skin and soft tissue (5 DOT) | 64 | 320 | 54 | 270 | 88 | 440 |
| Other (5 DOT) | 21 | 105 | 9 | 45 | 27 | 135 |
| Primary bloodstream (14 DOT) | 40 | 560 | 16 | 224 | 44 | 616 |
| Secondary bloodstream (14 DOT) | 8 | 112 | 4 | 56 | 4 | 56 |
| Total | 393 | 2938 | 229 | 1641 | 435 | 3174 |
| DOT per 10 000 encounters | .. | 9·8 | .. | 5·5 | .. | 10·6 |
| Enterobacteriaceae spp† | ||||||
| Urinary (5 DOT) | 222 | 1110 | 219 | 1095 | 5589 | 27 945 |
| Intra-abdominal (7 DOT) | 14 | 98 | 34 | 238 | 249 | 1743 |
| Lower respiratory (8 DOT) | 99 | 792 | 73 | 584 | 915 | 7320 |
| Skin and soft tissue (5 DOT) | 39 | 195 | 35 | 175 | 573 | 2865 |
| Other (5 DOT) | 10 | 50 | 16 | 80 | 134 | 670 |
| Primary bloodstream (14 DOT) | 52 | 728 | 56 | 784 | 774 | 10 836 |
| Secondary bloodstream (14 DOT) | 20 | 280 | 6 | 84 | 357 | 4998 |
| Total | 456 | 3253 | 439 | 3040 | 8591 | 56 377 |
| DOT per 10 000 encounters | .. | 10·9 | .. | 10·1 | .. | 188·2 |
Data are n or n per 10 000 encounters. DTR=difficult-to-treat resistance. DOT=days of therapy. CR=carbapenem resistant. ECR=extended-spectrum cephalosporin-resistant.
Hierarchical algorithm for generating market size estimates was applied to a dataset that included only the organism of interest individually; all categories (DTR, CR, and ECR) are mutually exclusive groups (CR category excludes episodes classified as DTR and ECR excludes episodes classified as DTR or CR); the term CR specifically refers to the subset of CR pathogens against which at least one first-line drug is active and hence not DTR.
Enterobacteriaceae spp is a summation of eight species evaluated individually (appendix p 11).