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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Clin Neuroradiol. 2019 Jan 18;30(2):251–261. doi: 10.1007/s00062-018-00757-x

Table 2.

Mean values of brain metabolite concentrations and coefficients of variance (COV) obtained by averaging corresponding values among the volunteers that were estimated with the methods as indicated

Metabolite Methodd BGf oGMf pWMf
Ne Mean COV (%) N Mean COV (%) N Mean COV (%)
NAA/tCr SVS-LCM 32 1.17 18.3 59 1.30a 8.3 59 1.43a,b 12.6
wbMRSI 59 1.09 12.5 59 1.26b 9.3 59 1.33a,c 10.1
Hybrid 59 1.10 13.7 59 1.21a,b 9.5 59 1.26b,c 11.2
tCho/tCr SVS-LCM 32 0.29a,b 21.3 59 0.16a,b 13.0 59 0.27a,b 16.6
wbMRSI 59 0.24a 16.1 59 0.14a 15.3 59 0.22a 15.1
Hybrid 59 0.25b 15.6 59 0.13b 14.2 59 0.22b 14.6
mIns/tCr SVS-LCM 25 0.70a 47.3 59 0.58a,b 15.2 59 0.76a,b 21.5
wbMRSI 57 0.41a,b 26.3 59 0.42a,c 17.9 59 0.47a,c 15.4
Hybrid 58 0.56b 35.7 59 0.63b,c 16.8 59 0.68b,c 14.6
Gln/tCr SVS-LCM 14 0.63 30.2 57 0.62a,b 19.5 42 0.59a 24.5
wbMRSI 29 0.51 30.5 47 0.46a 29.0 58 0.51b 27.8
Hybrid 47 0.48 33.8 43 0.45b 40.8 46 0.40a,b 37.6
Glu/tCr SVS-LCM 23 0.97a 25.5 59 1.00a 18.1 53 0.92a,b 22.3
wbMRSI 55 0.77b 25.0 59 1.03b 15.1 58 1.01a,c 18.2
Hybrid 50 0.55a,b 28.3 59 0.71a,b 20.2 58 0.63b,c 24.9
Linewidth (Hz) SVS-LCM 32 10.07a,b 20.2 59 6.43 19.9 59 6.17 23.2
wbMRSI 59 7.91a,c 12.1 59 6.38a 15.6 59 6.35a 9.9
Hybrid 59 7.32b,c 14.1 59 5.93a 18.6 59 5.90a 11.3
a

The suffixed letter a, b, or c indicate the paired metabolite values of different methods in same brain structure were significantly different that estimated by using rANOVA with Bonferroni post hoc test

b

The suffixed letter a, b, or c indicate the paired metabolite values of different methods in same brain structure were significantly different that estimated by using rANOVA with Bonferroni post hoc test

c

The suffixed letter a, b, or c indicate the paired metabolite values of different methods in same brain structure were significantly different that estimated by using rANOVA with Bonferroni post hoc test

d

SVS-LCM spectral data were scanned with SVS and analyzed with LCModel, wbMRSI data were scanned with EPSI and analyzed with MIDAS, Hybrid data were scanned with EPSI and analyzed with LCModel

e

N represents the number of sampled subjects. The data with line width >14Hz, Cramer-Rao lower bound >20% for NAA, tCho, and tCr, and >30% for Gln, Glu and MI were not sampled

f

BG represents the ROI in basal ganglia, oGM the ROI in occipital grey matter, and pWM the ROI in parietal white matter