. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: Clin Neuroradiol. 2019 Jan 18;30(2):251–261. doi: 10.1007/s00062-018-00757-x

Table 3.

Mean Cramer-Rao lower bounds (CRLB) of the spectral data analysis

Metabolite	Method^a	BG^c		oGM^c		pWM^c
		N^b	CRLB	N	CRLB	N	CRLB
NAA	SVS-LCM	32	8% ± 2%	59	5% ± 1%	59	5% ± 1%
	wbMRSI	59	4% ± 1%	59	4% ± 1%	59	3% ± 1%
	Hybrid	59	3% ± 1%	59	2% ± 0%	59	2% ± 0%
tCho	SVS-LCM	32	9% ± 3%	59	9% ± 1%	59	7% ± 1%
	wbMRSI	59	6% ± 1%	59	9% ± 3%	59	5% ± 1%
	Hybrid	59	4% ± 1%	59	6% ± 1%	59	4% ± 1%
tCr	SVS-LCM	32	8% ±3%	59	5% ± 1%	59	6% ± 1%
	wbMRSI	59	3% ± 1%	59	4% ± 1%	59	3% ± 1%
	Hybrid	59	3% ± 0%	59	3% ± 1%	59	3% ± 0%
mI	SVS-LCM	25	14% ± 5%	59	10% ± 3%	59	10% ± 3%
	wbMRSI	57	11% ± 4%	59	10% ± 3%	59	8% ± 2%
	Hybrid	58	8% ± 4%	59	6% ± 1%	59	5% ± 1%
Gln	SVS-LCM	14	22% ± 4%	57	18% ± 4%	42	22% ± 5%
	wbMRSI	29	22% ± 5%	47	18% ± 6%	58	15% ± 4%
	Hybrid	47	18% ± 5%	43	18% ± 6%	46	19% ± 6%
Glu	SVS-LCM	23	18% ± 5%	59	13% ± 4%	53	16% ± 5%
	wbMRSI	55	13% ± 5%	59	7% ± 3%	58	6% ± 2%
	Hybrid	50	15% ± 5 %	59	10% ± 3%	58	11% ± 4%

SVS-LCM spectral data were scanned with SVS and analyzed with LCModel, wbMRSI data were scanned with EPSI and analyzed with MIDAS, Hybrid data were scanned with EPSI and analyzed with LCModel

N represents number of sampled subjects. The data with linewidth >14Hz, Cramer-Rao lower bound >20% for NAA, tCho, and tCr, and >30% for Gln, Glu and MI were not sampled

BG represents the ROI in basal ganglia, oGM the ROI in occipital grey matter, and pWM the ROI in parietal white matter