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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Hum Genet. 2019 Dec 5;139(6-7):759–768. doi: 10.1007/s00439-019-02091-9

Table 2. Common variants associated with infectious diseases.

Data from the GWAS catalog (March 2019) on the number of associated variants (n=484, strongest/lead risk allele) with 22 infectious agents and disease traits (*).

Region No. variants* %
Intron 194 40
HLA** 120 25
Intergenic 96 20
Regulatory region 33 7
Coding 16 3
Non-coding transcript 9 2
TF-binding site 7 1.5
5UTR 5 1
3UTR 4 1
*

Associated with: acne, bacterial meningitis, chickenpox, enteric fever, Epstein-Barr virus, Hepatitis B, Hepatitis C , HIV-1, HPV, Influenza A, leprosy, meningococcal disease, mononucleosis, mumps, nontyphoidal salmonellosis, pneumococcal bacteremia, rubella, malaria, shingles, Staphylococcus aureus, strep throat, tuberculosis, urinary tract infection.

**

More than half of the HLA associations map to non-coding regions in MHC.