. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Cancer Prev Res (Phila). 2020 Feb 26;13(6):521–530. doi: 10.1158/1940-6207.CAPR-19-0413

Table 4.

Associations of genotypes with season-adjusted serum 25(OH)D among Caucasian men in the PCPT placebo arm.

			Number of minor alleles
rs number	Allele		0		1		2
	Major	Minor	Case/Ctl	Mean 25(OH)D¹	Case/Ctl	Mean 25(OH)D¹	Case/Ctl	Mean 25(OH)D¹
rs1544410	G	A	222/233	59.44	301/315	58.75	100/101	60.61
rs11568820	G	A	405/418	58.19	206/207	61.67	22/26	59.45
rs757343	G	A	482/489	59.51	138/153	58.59	8/8	61.61
rs11574143	G	A	523/525	59.26	107/122	59.83	3/6	54.10
rs7041	C	A	186/199	62.48^**	312/314	59.14^**	127/139	55.60^**
rs222014	G	A	508/509	59.23	117/134	59.52	7/9	63.86
rs222016	A	G	455/460	59.02	166/169	60.10	11/24	59.80
rs705117	A	G	466/466	59.30	152/171	58.61	14/16	66.53
rs2282679	A	C	311/325	61.90^**	264/270	58.03^**	60/60	52.13^**
rs12512631	A	G	287/313	57.14^**	281/267	60.46^**	64/72	64.86^**
rs6599638	G	A	179/206	59.42	304/309	59.31	141/129	59.70
rs2060793	G	A	237/249	57.34^**	294/304	59.79^**	103/99	63.04^**
rs2248359	G	A	241/224	59.67	309/303	59.96	79/122	56.74^†
rs2762942	A	G	570/572	59.24	60/81	60.18	5/1	59.31
rs4809958	A	C	460/466	59.50	159/174	59.08	13/13	56.21
rs6013897	T	A	391/378	60.07	210/243	58.06	31/30	59.10
rs6022999	A	G	364/382	59.71	238/228	59.40	31/44	54.98
rs703842	A	G	282/303	59.18	271/279	58.57	81/67	62.58
rs1790349	A	G	443/472	59.47	167/168	58.53	22/14	63.21
rs3829251	G	A	442/457	59.91	159/173	57.13	21/15	64.36
rs12785878	A	C	349/350	60.97^**	240/251	57.71^**	45/52	56.20^**

Means are geometric means.

<49.5 nmol/L

49.5–66.9 nmol/L

⁴

≥66.9 nmol/L

^**

P-value comparing mean serum 25(OH)D concentration by genotype significant after a within gene Bonferroni adjustment, calculated using linear regression with log[25(OH)D] as dependent variable. Significance thresholds among genes were: VDR = 0.013 (4 tests), GC = 0.008 (6 tests), C10corf88 = 0.05 (1 test), CYP2R1= 0.05 (1 test), CYP24A1 = 0.01 (5 tests), CYP27B1 = 0.05 (1 test), DHCR7= 0.05 (1 test), and NADSYN1 = 0.025 (2 tests).

^†

P-interaction = 0.049 for test of serum 25(OH)D x SNP interaction in relation to prostate cancer risk. All other p-interaction tests>0.10