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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2020 May 5;19(6):1255–1265. doi: 10.1158/1535-7163.MCT-19-0931

Figure 5:

Figure 5:

In vitro and in vivo γH2AX analysis after combined radiation and AZD4547 treatment in NCI-H226 and NCI-H1581 cell lines. Representative immunofluorescence γH2AX foci images and foci quantification for (A) NCI-H226 cells grown in vitro, (B) NCI-H226 cells grown in vivo and (C) NCI-H1581 cells grown in vivo. In vitro NCI-H226 cells were treated with DMSO, AZD4547 (0.1 μM), radiation (3 Gy) or combined AZD4547 (0.1 μM) and radiation (3 Gy) and analyzed at designated time points. NCI-H1581 and NCI-H226 xenografts were treated with DMSO, AZD4547 (6.25 or 12.5 mg/kg), radiation (2 Gy single dose) or combined AZD4547 (6.25 or 12.5 mg/kg) and radiation (2 Gy single dose). Columns, mean; bars, SEM (n=3).