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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Cancer Res. 2020 Mar 3;80(11):2094–2100. doi: 10.1158/0008-5472.CAN-19-3126

Figure 4. ATM Loss Confers Sensitivity to ATR Inhibition.

Figure 4.

A. Immunoblot analysis reveals that the ATR inhibitor M6620 (VX-970) inhibits IR-induced ATR auto-phosphorylation (upper band, denoted by arrow) and ATR-mediated KAP1 phosphorylation in prostate cancer cell lines. B. ATM deletion results in increased sensitivity to the ATR inhibitor VX-970 across prostate cancer cell line models as measured by 3–4 day cell viability (left) or 10–14 day clonogenic survival (right). C. ATM depletion by siRNA also increases sensitivity to ATR inhibition. Data are plotted as mean ± standard deviation of three independent experiments. Astericks (*) denote p<0.05. IR, ionizing radiation.