Fig. 3.

Loss of body and hindlimb muscle weight during disease progression in SBMA mice. (A) Body weight did not differ between WT and AR100 mice at 3 or 6 months of age. However, at both 12 and 18 months, AR100 mice weighed significantly less than WT and AR20 mice. (B) TA muscle weight was slightly higher in AR100 mice at 3 months. However, at 6, 12 and 18 months of age there was a significant reduction in TA muscle weight in AR100 mice compared to WT control mice. (C) There was no difference in EDL muscle weight between AR100 and WT and AR20 mice at 3 months. At 6, 12 and 18 months, however, the weights of EDL muscles in AR100 mice were considerably less than those of WT and AR20 mice. (D) Soleus muscle weights did not alter considerably over the course of disease; however, at the 18 month time point the difference just reached the threshold for statistical significance. Statistical analysis was performed using repeated measure or one-way ANOVA followed by the Student–Newman–Keuls and Tukey's Honestly Significantly Different post hoc tests (n≥5 animals, *P<0.05). Error bars represent s.e.m.