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. 2020 May 27;133(10):jcs241687. doi: 10.1242/jcs.241687

Fig. 4.

Fig. 4.

Human iPSC-derived neurons with tau pathology display changed passive membrane properties during extended neurogenesis. (A) Membrane capacitance (Cm) of iPSC-derived neurons in control cell lines (non-demented group) and in cell lines obtained from two patients (FTDP-17 group) at 100 and 150 DIV. Left plots show pooled data at 100 DIV (n=17 in control, n=7 in FTDP-17) and 150 DIV (n=37 in control, n=66 in FTDP-17). Scatter plots demonstrate the parameter distribution for each individual case (i and ii) at 150 DIV (FTDP-i, n=32; FTDP-ii, n=34). Lines represent median values (nonparametric Mann–Whitney test values are indicated). (B) Membrane constant (τm) in control neurons and neurons with the mutation at 100 DIV (n=17 in control, n=7 in FTDP-17) and 150 DIV (n=37 in control, n=66 in FTDP-17). (C) Same as for B, but for the input resistance (Rin); notations as in B. (D) Same as for A, but for the resting membrane potential (Vrest). Right, pooled data at 100 DIV (n=10 in control, n=5 in FTDP-17) and 150 DIV (n=24 in control, n=51 in FTDP-17). Scatter plots show the parameter distribution per case at 150 DIV (FTDP-i, n=22; FTDP-ii, n=24). Lines represent median values. ***P<0.001 (nonparametric Mann–Whitney test). Data are mean±s.e.m. unless indicated otherwise. *P<0.05; ***P<0.001 (ANOVA with Bonferroni post-hoc test); ###P<0.001 (150 DIV versus 100 DIV for control); §§§P<0.001 (150 DIV versus 100 DIV for FTDP-17 groups).