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. 2020 Jun 4;11(6):420. doi: 10.1038/s41419-020-2629-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Immunohistochemical staining of HOXA5 in clinical samples, including normal cervix (NC, n = 42), high-grade squamous intraepithelial lesion (HSIL, n = 28), and cervical carcinomas (CC, n = 55), original magnification, 1000×. b The immunohistochemical staining intensity was classified into negative, weak positive, and strong positive, and the percentage of each group was shown. c The scatter plots showed the IHC scores obtained for the staining of HOXA5 in different cervix lesion samples (points represent the IHC score per specimen, Student’s t-test is performed). d HOXA5 expression was detected by western blot in eight normal cervix samples and eight cervical carcinoma samples. GAPDH was used as loading control. e The quantitative illustration of the levels of HOXA5 protein using densitometry to measure the density of the corresponding bands in (d). Student’s t-test was carried out. f The HOXA5 mRNA expression level of clinical cervical cancer samples and normal cervix samples, data were obtained from GEO database. *p < 0.05, **p < 0.01, ***p < 0.001.